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- The Eugenics Wars begin, a terrible conflict on Earth brought about by a group of genetically engineered "supermen" who were the result of an ambitious selective-breeding program. The leader of the group is Khan Noonien Singh and since 1992, he and his followers seized control in forty Earth nations, which totalled roughly a quarter of the planet. Terrible wars ensue, in part because the "supermen" fought among themselves. Entire populations were bombed out of existence, ferocious battles were being fought and Earth was on the verge of a new Dark Age. (TOS: "Space Seed")
- The novel series Star Trek: The Eugenics Wars depicts the events around Khan's rise to power and the ensuing wars during the 1990s.