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- Christopher Pike assumed command of USS Enterprise, and takes the ship on its second five-year mission. (TOS: "The Menagerie, Part I", "The Menagerie, Part II")
- Leonard McCoy participated in a medical mission to Dramia II to lead an inoculation program, for the Saurian virus, on that planet. Nineteen years later, in 2270 he was put under arrest by Commander Demos and held responsible for the outbreak of the auroral plague. (TAS: "Albatross")