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The Argolis Cluster was an area of space containing a protostar cluster, as well as six star systems. One of these systems, the Tagra planetary system, was the location of the inhabited Tagra IV. This was the homeworld of the Tagrans. (TNG: "I Borg", "True Q")
In 2368, the USS Enterprise-D conducted a survey of the Argolis Cluster's star systems as a possible prelude to Federation colonization. During the survey, it discovered a crashed Borg scout ship with one surviving drone, who would later be known as Hugh. A few months later in 2369, the Enterprise returned to the Argolis Cluster to provide ecological assistance to Tagra IV. (TNG: "I Borg", "True Q")
During the Dominion War, the Dominion concealed a large sensor array at the periphery of the Argolis Cluster. The array allowed them to monitor allied ship movements over five sectors, providing them with a substantial tactical advantage. In 2374, the USS Defiant, commanded by Lieutenant Commander Jadzia Dax, successfully destroyed the array by moving through the cluster instead of around it. The Dominion forces were unprepared for an attack from that direction, as they believed any ship inside the cluster would be destroyed by the extreme gravimetric shear. (DS9: "Behind the Lines")