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Burke could refer to:
- Burke (Chief), a soldier, ranked chief, who fought on Ajilon Prime
- Burke (Ensign), Ensign of the USS Enterprise-D
- Burke (Yeoman), Yeoman of the USS Enterprise-A
- John Burke, an astronomer of the 21st century
- Helen Burke, mayor of the city of San Francisco
- Maxwell Burke, of the USS Equinox
- Astronomical objects
- Burke (comet), a comet orbiting Sol until the mid-22nd century
- Billy Burke, the actor who played Ari
- Michael Reilly Burke, the actor who played Koss
- Solomon Burke, Jr., the actor who played Billy
- Ron Burke, one of the actors to play a native in "The Apple"
- Martin R. Burke, author of The Chance Factor