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Columbia might refer to:
- Space Shuttle
- Columbia, a 22nd century United Earth Starfleet starship (NX-02)
- SS Columbia, an early 23rd century American Continent Institute survey vessel
- USS Columbia, a late 23rd century Federation Starfleet starship
- Columbia personnel, the crew of the aforementioned United Earth Starfleet starship Columbia
- SS Columbia personnel, the crew of the SS Columbia
- Columbia Records, a record company that released a Star Trek record