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Loren III was one of the planets seeded with part of a genetic program by the ancient humanoids 4.5 billion years ago. In 2369, Professor Richard Galen collected a DNA sample from Loren III as part of his quest to piece together the program, though it was taken by the Yridians. The USS Enterprise-D returned to the planet to collect another sample, where it encountered two Cardassian cruisers and the IKS Maht-H'a. (TNG: "The Chase")