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In 2267, the Botany Bay was discovered by the USS Enterprise, where he was one of the 72 surviving male members of Khan's original group of 84. Otto was banished to Ceti Alpha V with Khan. (TOS: "Space Seed") 6 months later however Ceti Alpha XI exploded and laid waste to Ceti Alpha V, leaving only the transported cargo crates as shelter.
Weather he survived to serve Khan on the stolen USS Reliant 15 years later or was killed by the life forms of the planet is unknown. What ever the case, Otto would be deceased. Star Trek II: The Wrath of Khan