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Symbalene blood burn was a deadly and extremely contagious disease that could kill a Human in a few minutes. The pathogen caused the vascular lining to literally boil away. Initial symptoms included a critical rise in body temperature and blood pressure, followed by extreme pain in the extremities, rupture of capillaries, and death. Although extraordinarily contagious and capable of acting across mass populations, not even the Symbalene blood burn could kill an entire planetary population of four billion in under a week. (TOS: "The Changeling"; ENT: "Cold Station 12")
Samples of Symbalene blood burn were stored at Starfleet's Cold Station 12 for study. In 2154, a group of Augments led by Arik Soong exposed one of the doctors there to Symbalene blood burn in an effort to force Doctor Jeremy Lucas to give them the access codes for the stored Augment embryos. (ENT: "Cold Station 12")
Information about Symbalene blood burn was contained within the Starfleet Medical Database, where Lieutenant Reginald Barclay learned about it. In 2370, Barclay thought that he perhaps had Symbalene blood burn after Dr. Beverly Crusher assured him that he did not have Terellian Death Syndrome. (TNG: "Genesis")